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KMID : 0624620110440050291
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BMB Reports
2011 Volume.44 No. 5 p.291 ~ p.297
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Genomic approaches for the understanding of aging in model organisms
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Park Sang-Kyu
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Abstract
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Aging is one of the most complicated biological processes in all species. A number of different model organisms from yeast to monkeys have been studied to understand the aging process. Until recently, many different age-related genes and age-regulating cellular pathways, such as insulin/IGF-1-like signal, mitochondrial dysfunction, Sir2 pathway, have been identified through classical genetic studies. Parallel to genetic approaches, genome-wide approaches have provided valuable insights for the understanding of molecular mechanisms occurring during aging. Gene expression profiling analysis can measure the transcriptional alteration of multiple genes in a genome simultaneously and is widely used to elucidate the mechanisms of complex biological pathways. Here, current global gene expression profiling studies on normal aging and age-related genetic/environmental interventions in widely-used model organisms are briefly reviewed.
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KEYWORD
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Aging, C. elegans, DNA microarray, Drosophila melanogaster, Mice, Transcriptional profiling
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